| 中文名称 |
53BP1 Rabbit mAb |
| 储存条件 |
-20°C/1 year |
| 基因名称 |
53BP1 |
| 蛋白名称 |
Tumor suppressor p53-binding protein 1 |
| 其他名称 |
TP53BP1;Tumor suppressor p53-binding protein 1;53BP1;p53-binding protein 1;p53BP1 |
| Gene Id |
7158 |
| Swissprot Number |
Q12888 |
| 宿主种属 |
Rabbit |
| 应用范围 |
WB, |
| 稀释比例 |
WB 1:1000-5000； |
| 反应种属 |
Human, |
| 克隆性 |
Monoclonal |
| 特异性 |
endogenous |
| 同种型 |
Rabbit IgG |
| 保存液 |
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| 纯化方式 |
Protein A |
| 背景资料 |
This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] |
| 蛋白分子量 |
MW(Calculated):214kD;MW(Observed):450kD |
