| 中文名称 |
STAT3 (Phospho Ser727) Rabbit mAb |
| 储存条件 |
-20°C/1 year |
| 基因名称 |
Stat3 |
| 蛋白名称 |
Signal transducer and activator of transcription 3 |
| 其他名称 |
STAT3;APRF;Signal transducer and activator of transcription 3;Acute-phase response factor |
| Gene Id |
6774 |
| Swissprot Number |
P40763 |
| 宿主种属 |
Rabbit |
| 应用范围 |
mIHC;IHC |
| 稀释比例 |
mIHC 1:1000-3000,IHC 1:100-300 |
| 反应种属 |
Mouse,Rat,Human |
| 克隆性 |
Monoclonal |
| 特异性 |
endogenous |
| 同种型 |
Rabbit IgG |
| 保存液 |
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| 纯化方式 |
Protein A |
| 背景资料 |
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper |
| 蛋白分子量 |
MW(Calculated):88kD;MW(Observed):88kD |
