| 中文名称 |
STAT6 (Phospho Tyr641) Rabbit mAb |
| 储存条件 |
-20°C/1 year |
| 基因名称 |
Stat6 |
| 蛋白名称 |
Signal transducer and activator of transcription 6 |
| 其他名称 |
STAT6;Signal transducer and activator of transcription 6;IL-4 Stat |
| Gene Id |
6778 |
| Swissprot Number |
P42226 |
| 宿主种属 |
Rabbit |
| 应用范围 |
mIHC;IHC |
| 稀释比例 |
mIHC 1:1000-3000,IHC 1:100-300 |
| 反应种属 |
Mouse,Rat,Human |
| 克隆性 |
Monoclonal |
| 特异性 |
endogenous |
| 同种型 |
Rabbit IgG |
| 保存液 |
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| 纯化方式 |
Protein A |
| 背景资料 |
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010], |
| 蛋白分子量 |
MW(Calculated):94kD;MW(Observed):110kD |
