| 中文名称 |
Arginase-1 Rabbit pAb |
| 储存条件 |
-20°C/1 year |
| 基因名称 |
Arginase 1 |
| 蛋白名称 |
Arginase 1 |
| 其他名称 |
ARG1, Arginase 1, liver Arginase, ARG 1, Arg-1 |
| Gene Id |
383 |
| Swissprot Number |
P05089 |
| 宿主种属 |
Rabbit |
| 应用范围 |
mIHC;IHC |
| 稀释比例 |
mIHC 1:1000-3000,IHC 1:100-300 |
| 反应种属 |
Mouse, Rat, Human |
| 克隆性 |
polyclonal |
| 特异性 |
endogenous |
| 同种型 |
Rabbit IgG |
| 保存液 |
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 纯化方式 |
Protein A |
| 背景资料 |
Arginase-1 (Liver arginase) belongs to the arginase family. ARG1 is a novel immunohistochemical marker of hepatocellular differentiation in fine needle aspiration cytology and a marker of hepatocytes and hepatocellular neoplasms. ARG1 is closely associated with alternative macrophage activation and ARG1 has been shown to protectmotor neurons from trophic factor deprivation and allow sensory neurons to overcome neurite outgrowth inhibition by myelin proteins (PMID: 20071539, PMID:12098359). It can exsit as a homotrimer and it has 3 isoforms produced by alternative splicing (PMID:16141327). Defects in ARG1 are the cause of argininemia (ARGIN). Deletion or TNF-mediated restriction of ARG1 unleashes the production of NO by NOS2, which is critical for pathogen control (PMID:27117406). ARG1 mainly expresses in neurons in a normal brain. The expression of ARG1 increases in microglia/macrophages and astrocytes early after CNS injuries. ARG1 has been regarded as a marker for beneficial microglia/macrophages and possesses antiinflammatory and tissue repair properties under various pathological conditions (PMID: 26538310, PMID: 31619589). |
| 蛋白分子量 |
35-36 kDa |
