| 中文名称 |
p16 Rabbit mAb |
| 储存条件 |
-20°C/1 year |
| 基因名称 |
p16 |
| 蛋白名称 |
p16 |
| 其他名称 |
Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3;Cyclin-dependent kinase 4 inhibitor A;CDK4I;Multiple tumor suppressor 1;MTS-1;p16-INK4a;p16-INK4;p16INK4A;p16; |
| Gene Id |
,12578 |
| Swissprot Number |
,P51480 |
| 宿主种属 |
Rabbit |
| 应用范围 |
mIHC;IHC |
| 稀释比例 |
mIHC 1:1000-3000,IHC 1:100-300 |
| 反应种属 |
Mouse |
| 克隆性 |
Monoclonal |
| 特异性 |
endogenous |
| 同种型 |
Rabbit IgG |
| 保存液 |
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| 纯化方式 |
Protein A |
| 背景资料 |
p16 (also known as p16INK4a, cyclin-dependent kinase inhibitor 2A, CDKN2A, multiple tumor suppressor 1 and numerous other synonyms), is a protein that slows cell division by slowing the progression of the cell cycle from the G1 phase to the S phase, thereby acting as a tumor suppressor. It is encoded by the CDKN2A gene. A deletion (the omission of a part of the DNA sequence during replication) in this gene can result in insufficient or non-functional p16, accelerating the cell cycle and resulting in many types of cancer. p16 can be used as a biomarker to improve the histological diagnostic accuracy of grade 3 cervical intraepithelial neoplasia (CIN). p16 is also implicated in the prevention of melanoma, oropharyngeal squamous cell carcinoma, cervical cancer, vulvar cancer and esophageal cancer. p16 was discovered in 1993. It is a protein with 148 amino acids and a molecular weight of 16 kDa that comprises four ankyrin repeats. The name of p16 is derived from its molecular weight, and the alternative name p16INK4a refers to its role in inhibiting cyclin-dependent kinase CDK4. |
| 蛋白分子量 |
MW(Calculated):17kD;MW(Observed):17kD |
