| 中文名称 |
P21 Rabbit mAb |
| 储存条件 |
-20°C/1 year |
| 基因名称 |
P21 |
| 蛋白名称 |
P21 |
| 其他名称 |
CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1, p21, cyclin-dependent kinase inhibitor 1A, cyclin dependent kinase inhibitor 1A |
| Gene Id |
1026 |
| Swissprot Number |
P39689 |
| 宿主种属 |
Rabbit |
| 应用范围 |
mIHC;IHC |
| 稀释比例 |
mIHC 1:1000-2000,IHC 1:200-500 |
| 反应种属 |
Mouse |
| 克隆性 |
Monoclonal |
| 特异性 |
endogenous |
| 同种型 |
Rabbit IgG |
| 保存液 |
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| 纯化方式 |
Protein A |
| 背景资料 |
May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding. |
| 蛋白分子量 |
18kDa |
